Sam-e is a naturally occurring molecule in the body that stabilizes mood and promotes healthy brain function. Sam-e is scientifically known as s-adenosylmethionine. Low levels of Sam-e is the trigger point for depression because Sam-e helps regulate various hormones and neurotransmitters, including serotonin, melatonin, dopamine, and adrenaline. A process taking place with these molecules is known as Methylation; which affects everything from the expression of genes to brain function. Sam-e is present in every living cell in the body. However, levels tend to decline with age.
Sam-e is a natural alternative for anti-depressants. It is used for depression, infertility, liver concerns, premenstrual disorders, psychiatric illnesses, musculoskeletal, in addition to others. Many consumers have found that it has increased their mood, lowered anxiety, and had a much better night of sleep. Some even have claimed it is the best that they have felt in years; which makes sense. The reason for this is that Sam-e affects dopamine; which in your body is your happy neurotransmitter that plays a crucial role in your mood. The benefits of Sam-e have increased mood, mental alertness, reduction of osteoarthritis, and liver disease. Also, one will sleep better at night if Sam-e is taken earlier on in the day.
Side effects and warnings vary. However, here are the most common side effects, gastrointestinal with nausea, skin rashes, lowered blood sugar, and increased blood pressure. In addition to other reported side effects when taken by mouth or by injection, Sam-e may cause a hot sensation and itchiness of the ear, nausea, vomiting, dry mouth, heartburn, blood in the stool, anorexia, mild diarrhea, stomachaches, slight constipation, increased thirst, increased salivation, urinary frequency, intolerable bowel symptoms, gas, decreased appetite, anxiety, insomnia, hypomania, hostility, insomnia, elevated mood, psychoactivation, headache, suicidal ideation, hyperactivity, a reduced need for sleep, and bursts of energy.
In bipolar patients specifically, there were reports of anxiety and hypomania. Hypomania is increased irritability. It is best to check with your doctor before taking it. Any person with an allergy or hypersensitivity to s-adenosyl-l-methionine should be warned that symptoms such as flushing, reddening of the skin, palpitation, dizziness, and nausea have been reported in allergic patients. In pregnancy, Sam-e moves across the placenta. However, there is a lack of scientific evidence of taking Sam-e during pregnancy, so it is best to consult your doctor. Lastly, Parkinson’s Disease sufferers should avoid Sam e.
Overall, Sam-e supplements are a natural alternative for depression among other related problems mentioned above. It has been known to cause certain side effects, but according to consumers, there have been positive effects for many. It is best to monitor your Sam-e dosage and adjust accordingly depending on how your body is responding to the supplement. Most importantly, consult your doctor before use.
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