SAM-e or S-Adenosylmethionine is a naturally occurring substance which everyone’s body produces naturally. S -Adenosylmethionine is a methyl donor and protein, and is vital for tens of crucial processes in our bodies. In addition to many other functions, S -Adenosylmethionine regulates various hormones and neurotransmitters such as serotonin, melatonin, and dopamine. Malfunction or low levels of these hormones and neurotransmitters are associated with depression and low moods. Taking a SAM-e supplement increases your levels of S-Adenosylmethionine, naturally boosting your overall health, mood balance as well as your liver and joint health.

SAM-e As An Anti-Depressant

Many people who suffer from depression look for natural remedies in the place of standard anti-depressants. One popular option is SAM-e supplements. Taking SAM-e supplements acts as an effective anti-depressant by boosting the natural levels of S-Adenosylmethionine in people’s bodies. People who are depressed show lower levels S- adenosylmethionine, in their blood. “There’s a correlation between low levels of SAM-e and depression,” says Richard Brown, M.D., associate professor of psychiatry at Columbia University.

Being that it is a natural substance, and is so integral to the body’s overall health, taking SAM-e can only be of benefit. Says Brown: “I’d rather give depressed people something that does good things in their bodies as they get older.” Many research studies have shown that SAM-e works as well as standard prescription anti-depressants, but with few negative side effects and many positive effects on the body’s overall health.

Not All SAM-e Is The Same

Prescription drugs are closely monitored by the FDA and must adhere to strict standards and guidelines. Because SAM-e is a natural substance and is regarded as a non-prescription remedy in the USA, SAM-e quality & standards of effectiveness vary widely. In addition, often the product labeling can be misleading. Many companies advertise the milligrams in their products based on a count which includes the inactive ingredients, while the active ingredient is only half of the milligrams reported on the label.

Other factors that affect the efficacy of SAM-e are the packaging and tablet coating. Since it is hygroscopic, exposure to light and air degrades its quality. Additionally, it is important that the tablets be enteric-coated, to ensure that it is absorbed properly in the digestive tract. The enteric coating ensures that the tablet is not broken down in the stomach, where it can’t be used by the body, but remains intact until it is ready to be absorbed in the small intestines.






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